Although the response of renal cyst of VHL disease to TKIs has not been reported in previous research, we found that some TKIs were used to treat autosomal-dominant polycystic kidney disease (ADPDK) in previous literature; the research considered that TKIs can be used to decrease EGFR tyrosine kinase activity and collecting tubule cyst formation and enlargement in polycystic kidney disease (29, 30). Here, EGFR is linked to cystic kidney disease.