Gene promoter hypermethylation of DKK3 is reported in malignant biliary stricture (11), gastrointestinal cancer (46), prostate cancer (47), and acute lymphoblastic leukemia (48) leading to a speculation that epigenetic alteration of DKK3 gene promoter region may be major regulatory mechanism commonly associated with tumorigenesis. This evidence concerns the gene DKK3 and acute lymphoblastic leukemia.