DKK3 is reported as overexpressed in esophageal adenocarcinoma (35), head and neck squamous cell carcinoma (36), and hepatoblastoma (37); whereas studies have reported its downregulated in pancreatic cancer (38), clear cell renal cell carcinoma (39), gastric cancer (40), basal subtype of breast cancer (41), and melanoma (42). Here, DKK3 is linked to familial pancreatic carcinoma.