MMP12 and neoplasm: Contributes to tumor invasiveness by stimulating TAMs to increase gene expression of mmp2, mmp9, mmp12, and ctsl proteasesPromotes transformation from M1 to M2 phenotypeAdrenergic activation increased macrophage infiltration into tumor leading to progressionCatecholamines stimulate macrophage production of pro-inflammatory cytokinesHigh levels of stress were associated to TAM derived MMP9Characterization of adrenergic regulated macrophages