Enzyme-inducing AEDs, such as phenobarbital, phenytoin, and carbamazepine, can directly suppress gonadal testosterone synthesis [186], increase hepatic synthesis of sex hormone-binding globulin (SHBG) [187], and increase serum E2 levels, either in absolute concentrations or relative to bioavailable testosterone (BAT), and are associated with hyposexuality and hypogonadism [188, 189]. Here, SHBG is linked to hypogonadism.