In this regard, it has been shown that the use of benidipine reduced oxidative stress in PMNs of hypertensive patients, at least in part by reducing BP levels [35], and that angiotensin II type 1 receptor (AT1R) blockers were able to normalize BP and to reduce the oxidative stress produced by leukocytes, thus suggesting that the latter plays an active role in the pathogenesis of hypertension through the production of oxidative stress. The gene discussed is AGTR1; the disease is Hypertension.