The causal relation between heightened sympathetic tone and increased cardiovascular risk was documented in patients with end-stage renal disease, who lack renalase; therefore, it was proposed that the application of recombinant renalase may exert a cardioprotective role [8–13, 17], while in patients with advanced chronic kidney disease, soluble renalase was proven to be a predictor of all-cause mortality [11]. This evidence concerns the gene RNLS and stage 5 chronic kidney disease.