In the entire cohort, the HER2 expression was not significantly correlated with that of other proteins, but instead, a positive correlation was found between the expression of SATB1 and NF-κB. Further studies with a larger group of patients combined with in vitro mechanistic experiments are required to fully elucidate the role and relationship of HER2, NF-κB, and SATB1 expression in gastric cancer progression, as well as to assess the clinical significance of their joint detection in GC tissue samples. This evidence concerns the gene ERBB2 and gastric cancer.