These reasons seem to be particularly accurate in the light of the study of Hedner et al., who have used the TMAs along with immunohistochemistry to evaluate SATB1 status in the European population of patients with adenocarcinoma in the upper gastrointestinal tract (esophagus, cardia, and stomach), and found the rate (31.18%) very similar to ours [82]. This evidence concerns the gene SATB1 and adenocarcinoma.