In the entire cohort, the HER2 expression was not significantly correlated with that of other proteins, but instead, a positive correlation was found between the expression of SATB1 and NF-κB. Further studies with a larger group of patients combined with in vitro mechanistic experiments are required to fully elucidate the role and relationship of HER2, NF-κB, and SATB1 expression in gastric cancer progression, as well as to assess the clinical significance of their joint detection in GC tissue samples. The gene discussed is SATB1; the disease is gastric cancer.