The expression of CK7, CD117, Claudin-7, and their combinations was significant in CHRCC when compared to CCRCC, type 1 PRCC, type 2 PRCC, and RO (p < 0.0001; p = 0.0003 for CK7+CD117 in CHRCC vs. PRCC, type 1), except for the expression of CK7 or Claudin-7 between CHRCC and type 1 PRCC and CD117 between CHRCC and RO. The gene discussed is CLDN7; the disease is chromophobe renal cell carcinoma.