For instance, Wingless-type MMTV integration site family member 1 (Wnt1), Wnt2, Wnt3, Wnt3a, Wnt8a, Wnt8b, Wnt10a, and Wnt10b activate the canonical Wnt signaling and promote tumor progression, while Wnt4, Wnt5a, Wnt5b, Wnt6, Wnt7a, Wnt7b, and Wnt11 stimulate the non-canonical Wnt pathway as tumor suppressors10. Here, WNT4 is linked to neoplasm.