The Wnt/β-catenin pathway-related signaling including Wnt ligands, GSK-3β, β-catenin, and β-catenin-mediated downstream genes play crucial roles in HCC progression, including hepatocytes malignant transformation, metastasis, chemoresistance, liver cancer stem cells, and formation of epithelial-mesenchymal transition17. Here, GSK3B is linked to liver cancer.