CD276 and neoplasm: Other researchers have found that B7-H3 is expressed at low levels in most normal tissues but is overexpressed in OSCC and is associated with tumor progression 23, 24 These results are not in accordance with the immune costimulatory function reported in earlier studies 22 We hypothesize that B7-H3 can promote OSCC progression independent of the immunoregulatory function of T cells.