EGFR and esophageal squamous cell carcinoma: TMPRSS11E (transmembrane protease, serine 11E) could suppress esophageal squamous cell carcinoma development by sensitizing cells to apoptosis under an apoptotic stimulus through downregulating the EGFR/AKT signaling pathway 20, but recently was found significantly upregulated in urinary bladder cancer patients 21, which was consistent with our study outcomes.