TMPRSS11E (transmembrane protease, serine 11E) could suppress esophageal squamous cell carcinoma development by sensitizing cells to apoptosis under an apoptotic stimulus through downregulating the EGFR/AKT signaling pathway 20, but recently was found significantly upregulated in urinary bladder cancer patients 21, which was consistent with our study outcomes. Here, TMPRSS11E is linked to esophageal squamous cell carcinoma.