It was found that patients with male gender, age £ 60 years old, anti-HCV-negative, HBsAg-negative, non-alcoholism, liver cirrhosis, Edmonson's histology grading 1-2, tumor size > 4 cm, presence of microvascular or macrovascular invasion, AFP £ 100 ng/mL, or AST > ALT, the “GG” genotype was significantly associated with shorter overall survival (Figure 2). The gene discussed is AFP; the disease is alcohol drinking.