Furthermore, we also investigate the expression of PRC1and TOP2A between normal liver and HCC tumor tissues by using the Human Protein Atlas website (https://www.proteinatlas.org/; accessed February 2, 2018) 35, 36, and found that both the protein expression of PRC1and TOP2A were upregulated in HCC tumor tissue, which detected by immunohistochemistry (Figure S1C-F). This evidence concerns the gene TOP2A and neoplasm.