In addition, GO and KEGG enrichment analysis demonstrated that the biological processes of toxic substance decomposition and metabolism processes (including drugs and ethanol), P450 pathway 42, 43, p53 pathway 40, alcohol dehydrogenase activity and cell death regulation in the functional assessment of DEGs have also been reported in previous studies in connection with HCC. Here, AKR1A1 is linked to hepatocellular carcinoma.