Single gene GSEA analysis suggest that both the high expression of PRC1 and TOP2A were markedly enriched in the cell cycle and DNA repair biological processes in GSE14520 (Figure 11A-L, Table S7-10) and TCGA (Figure 12A-L, Table S11-14) cohorts, which consistent with the GSEA analysis results between HBV-related HCC tumor and adjacent normal tissues in GSE14520. This evidence concerns the gene TOP2A and hepatocellular carcinoma.