Similar to the validation of survival analysis, ROC analysis of PRC1 (P < 0.001, AUC = 0.974, 95% CI = 0.958-0.990, Figure 9C) and TOP2A (P < 0.001, AUC = 0.964, 95% CI = 0.944-0.985, Figure 9D) in TCGA also performed well in distinguishing the HCC tumor and adjacent normal tissues. Here, TOP2A is linked to neoplasm.