Previous studies indicated that the increased level of sialylation at the sites of Asn207/211 of total serum Hp in patients with liver cirrhosis and hepatocellular carcinoma was detected compared with those in patients with hepatitis B virus and healthy individuals 16 and that the increased level of sialylation of total serum Hp in hepatocellular carcinoma patient was observed relative to patients with hepatitis C viral infection and chronic hepatitis C 28. Here, HP is linked to cirrhosis of liver.