The motif recognized by hnRNPA2B1 (GGAG) is carried by miR-1246, and hnRNPA2B1 sumoylation is 3 times higher in mutp53 CRC cells than in the WT CRC cells, suggesting that changes in this mechanism are involved in exosomal miR-1246 oncogenic properties. The gene discussed is HNRNPA2B1; the disease is colorectal carcinoma.