More recently, the association between hypertension and astrocyte swelling has been illustrated by an overexpression of astrocyte aquaporine-4 (AQP4) in 6-month-old SHR in which hypertension is settled, but not in the prehypertensive phase in 2-month-old SHR, nor in the developing phase of hypertension in 4-month-old SHR in comparison to age-matched WKY [63, 64]. Here, AQP4 is linked to hypertensive disorder.