Our previous research indicated that the H3K4 and H3K27 tri-methylation levels of the MCP1 promoter in CAD CD14+ monocytes were not different from non-CAD patients, but the H3 and H4 acetylation of the MCP1 promoter was increased in CD14+ monocytes from CAD patients (Xiao et al., 2018). This evidence concerns the gene CCL2 and coronary artery disorder.