Our results also reveal that there is a combined effect on unconjugated hyperbilirubinemia for c.-3275T > G as well as (TA)6>(TA)7 or c.211G > A in UGT1A1. Further, co-expression of c.211G > A of UGT1A1 and c.521T > C of SLCO1B1 has a cumulative effect on unconjugated hyperbilirubinemia. Here, UGT1A1 is linked to Hyperbilirubinemia.