PRKN and Alzheimer disease: The importance of CNVs in PRKN gene was supported by our results as well, since 23.5% of our solved cases (consistent either to oligogenic or AD inheritance) harboured PRKN exon rearrangement, which were presumed to be more deleterious, because they caused altered PRKN protein function by reorganising the protein structure (Pankratz et al., 2011).