ACAD8 and hyperinsulinemic hypoglycemia, familial, 4: Interestingly, all the three patients with Isobutyryl coa dehydrogenase deficiency were heterozygous for the c.1000C > T variant of ACAD8 (MIM* 604773) gene, and two patients were heterozygous for the c.286C > A variant, which has not been reported.