Two years later, Azuara et al. (2013) reported that the methylation status of transforming growth factor beta 2 (TGFB2), SLIT2, heparan sulfate-glucosamine 3-sulfotransferase 2 (HS3ST2), and transmembrane protein with EGF like and two follistatin like domains 2 (TMEFF2) in colorectal biopsies could be potential surrogates for an early diagnosis of colorectal dysplasia or CRC in high-risk patients with IBD. This evidence concerns the gene HS3ST2 and irritable bowel syndrome.