MLH1 and colorectal carcinoma: Methylation markers of ITGA4, TFPI2, FOXE1, SYNE1, APC, CDH13, MGMT and MLH1 have also proven to be high-performance screening tools for estimating individual risk for CRC or colorectal neoplasia in IBD patients (Papadia et al., 2014; Gerecke et al., 2015; Scarpa et al., 2016).