CRP and Crohn disease: In 2016, a spearman correlation analysis indicated that circulating miR-223 was not only correlated with ESR and hs-CRP, but also correlated with clinical activity index including Crohn’s Disease Activity Index (CDAI), Simplified Endoscopic Score for Crohn’s Disease (SES-CD), Mayo score, and Ulcerative Colitis Endoscopic Index of Severity (UCEIS) (Wang et al., 2016).