RUNX3 and colorectal carcinoma: In 2010, Garrity-Park et al. (2010) assessed the methylation status of ten potential genes in intestinal biopsies, and revealed significant associations between runt related transcription factor 3 (RUNX3), MINT1 (also known as APBA1) and COX-2 methylation and UC–CRC (OR=12.6, 9.0 and 0.2, respectively).