Overall, the loss of ALDH1L1 protein positively correlates with the occurrence of malignant tumors and tumor aggressiveness [reviewed in (Krupenko and Krupenko, 2018; Krupenko and Krupenko, 2019)], hence the suggestion that the enzyme is a candidate tumor suppressor (Senchenko et al., 2013). Here, ALDH1L1 is linked to neoplasm.