During natural infection with HIV, a subset of infected individuals develop broadly cross-neutralizing antibody responses against the Env gp160 glycoprotein (Li et al., 2007; Doria-Rose et al., 2009; Sather et al., 2009; Simek et al., 2009; Doria-Rose et al., 2010; Euler et al., 2010; Gray et al., 2011; Hraber et al., 2014; Landais et al., 2016). The gene discussed is ERVW-1; the disease is infection.