In the present study, we demonstrate that treatment with LsAg modulates CD4+ T cell activation during obesity via an adiponectin mediated mechanism and provide evidence for the role of the potential insulin sensitizing adipokine adiponectin in regulating T cell function by restraining Th1 and Th17 glycolysis during high fat diet (HFD). The gene discussed is CD4; the disease is obesity due to melanocortin 4 receptor deficiency.