CSF1R and infection: Interestingly, while investigating Ly6C+ monocytes in the spleen of mice infected with WT or PRF sporozoites on day 8 after infection, we found that mice with onset of ECM displayed a striking loss of CD115+Ly6C+ monocytes in spleen, which was neither apparent in PRF sporozoite-infected nor in naïve mice (Figures 6A,B).