In light of the documented role of Wnt5A signaling in cytoskeletal modulations and autophagy / xenophagy (3, 4, 30, 31), and the crucial involvement of actin and actin binding proteins during mycobacterial infections (55–57), it is important to examine how Wnt mediated cytoskeletal modulations regulate the sustenance vs. inhibition of mycobacterial infections. This evidence concerns the gene WNT5A and Mycobacterium infection.