Our findings also indicate that NTX does not affect TRPM3-dependent Ca2+ signals when directly applied on both IL-2 stimulated NK cells from non-fatigued controls and ME/CFS patients, suggesting that NTX does not act as an agonist by directly coupling on the TRPM3 ion channel gating mechanism. The gene discussed is TRPM3; the disease is myalgic encephalomeyelitis/chronic fatigue syndrome.