A previous genomic study suggested the importance of TRPM3 in the pathophysiology of ME/CFS and identified five single nucleotide polymorphisms (SNPs) (rs6560200, rs1106948, rs12350232, rs11142822, rs1891301) in TRPM3 genes in ME/CFS patients (30). This evidence concerns the gene TRPM3 and myalgic encephalomeyelitis/chronic fatigue syndrome.