In ANRIL gene, the rs944796 G allele, rs2518723 T allele frequencies were significantly increased in RA patients with anti-CCP-positive when compared to patients with anti-CCP-negative (all P < 0.05), while rs3217992 T allele frequency was reduced (P = 0.039) (Table 2). The gene discussed is CDKN2B-AS1; the disease is rheumatoid arthritis.