In multivariable analyses, detectable urinary properdin remained associated with development of graft failure (HR, 2.30; 95% CI 1.37–3.82; P < 0.001, Table 2), independent of adjustment for age, sex, primary renal disease, time since transplantation, eGFR, HLA mismatches, donor type, hs-CRP, systolic blood pressure, and smoking. The gene discussed is CFP; the disease is kidney disorder.