NFKB1 and viral infectious disease: In addition, the results from the luciferase reporter assay showed that the promoter activities of IFNh and NF-κB were significantly increased in LcTRIF overexpression cells, and this increase was more pronounced in the case of poly (I:C) stimulation, which illustrated that LcTRIF triggers both the IFNh and NF-κB pathways in response to virus infections.