CD27 and dengue disease: In parallel, frequencies of CD27+CD38hiCD138+ plasma cells were higher in dengue patients than in febrile controls (median, 4.1 vs. 0.9%; P < 0.01) and in DHF/DSS patients compared to DF patients (median, 7.1 vs. 1.9%; P < 0.05) (Figure 1E).