CD19+CD24hiCD38hi and CD19+CD27− B cells from dengue patients were refractory to TLR stimulation in vitro, resulting in decreased B-cell-specific IL-10 and TNF-α cytokine production, which correlates to an increased expression of inhibitory FcγR in vivo in naïve B cells from DENV-infected patients. This evidence concerns the gene TNF and dengue disease.