Here, the percentage of CD69+ and CD86+ naïve B cells remained significantly lower in B cells from dengue patients with respect to healthy donors even upon stimulation via BCR and TLR (median CD69+, 16.9 vs 40.2%; P < 0.05) (median CD86+, 26.5 vs 49.2%; P < 0.05) (Figure 5). This evidence concerns the gene CD69 and dengue disease.