Vibratory urticaria is an autosomal dominant autoinflammatory disease caused by mutations in the ADGRE2 gene, which encodes ADGRE2, a member of the epidermal growth factor seven transmembrane that acts as a cell surface receptor with two subunits, the extracellular α subunit and the transmembrane β subunit. The gene discussed is ADGRE2; the disease is vibratory urticaria.