However, Behçet-like disease associated with NFKB1 mutations was also associated with IgG-hypogammaglobulinemia, depletion of switched memory B cells and increased susceptibility to respiratory tract infections, thus overlapping somewhat with the immunodeficiency and autoimmunity phenotype described first for NFKB1-associated disease (175, 176). The gene discussed is NFKB1; the disease is immunodeficiency disease.