For instance, T1D patients present antibodies against a heat shock protein from the Mycobacterium avium subspecies paratuberculosis, MAP Hsp65, which has a high degree of homology with human GAD65, suggesting that cross-reactivity between MAP Hsp65 and GAD65 potentially could be a mechanism of triggering TID (32). Here, GAD2 is linked to type 1 diabetes mellitus.