Conversely, cDC1 provide efficient processing and cross-presentation of exogenous antigens on MHC I molecules to activate CD8+ T cells and TH1 cell responses as a response to tumor cells or intracellular pathogens (23, 24) and cDC2 are known to be inducers of CD4+ T cell responses (25, 26). The gene discussed is MPPE1; the disease is neoplasm.