TLR4 and herpes simplex infectious disease: At the acute phase (7 dpi), up-regulated genes were enriched in ribosome and DNA replication to activate host immune response (pathways of Toll-like receiver signal, Fc gamma R-mediated phagocytosis, Phagosome, and T cell receiver signaling) and defense against the pathogens via the pathways of measles, Epstein–Barr virus infection, herpes simplex infection, influenza A, leishmaniasis, pertussis, and S. aureus infection.