TNC and cancer: Besides, as the two most downregulated miRNAs by PMSG, miR-34b and miR-205-5p were reported to regulate cell apoptosis and cell-cycle arrest in many types of cancers, and among their common predicted target genes, LGALS9, TNC, and LIF are known as regulators of cell apoptosis, proliferation, and adhesion (42–44), suggesting that reduced levels of both miRNAs may promote PMSG-stimulated follicle maturation by regulating ovarian cellular proliferation and apoptosis.