GLP1R and type 2 diabetes mellitus: In the management guidelines for adults with T2DM, insulin or sulfonylureas are only added to the regimen if other medications (GLP-1 RAs, DPP-IV inhibitors and SGLT2 inhibitors) fail to achieve goal HbA1c as both insulin and sulfonylureas promote weight gain, which can worsen insulin resistance and overall health (10).