CP and Glucose intolerance: Based on the reliability value of CP in evaluating glucose metabolism and the high sensitivity (69.5%) and specificity (89.2%) of FCP in predicting improved glucose intolerance in this study, we believe that preoperative FCP reliably predicts surgical benefits in acromegaly patients with impaired glucose metabolism, with an 86.6% positive predictive value (PPV) and a 74.5% negative predictive value (NPV).