Taken together, CpG island methylation in the CRABP2 promoter region is evidenced in RA-resistant human ATC THJ-11T and medulloblastoma UW228-2 cells, which can be largely erased by resveratrol in the same manner as gemcitabine, demonstrating the ability of resveratrol in DNA demethylation. The gene discussed is CRABP2; the disease is medulloblastoma.