SLC1A2 and Parkinson disease: The hypothesis of increased glutamatergic projection in the course of PD and reduced glutamatergic tonus in response to physical activity has been strengthened by Scone et al. (21), who showed that while levels of vesicular glutamate transporter 1 (VGLUT1) and glutamate transporter-1 (GLT-1) were elevated after MPTP administration, the level of these transporters was decreased following physical activity, restoring glutamate homeostasis in treated mice.