Physical training in animal models of PD, beside neuroprotection of the dopaminergic system, may enhance neurogenesis and progenitor cell migration through upregulating BDNF-TrkB and GDNF-Ret signaling, which can, in turn, stimulate certain signaling cascades, including those that activate the PI3K/Akt pathway or the extracellular signal-regulated kinases 1 and 2 (ERK1/2) cascade. Here, GDNF is linked to Parkinson disease.