PRNP and Alzheimer disease: Multiple lines of evidence implicate soluble oligomers of Aβ in the pathogenesis of AD, which have been reported to interact with the phospholipid bilayers of the cell membrane, NMDA, and AMPA receptors, the metabotropic glutamate receptor 5, the insulin receptor, the nicotinic acetylcholine receptor α7-nAcChR, PrP, and other cellular components and membrane receptors (82).