APP and Alzheimer disease: Concerning transcriptomics, a single study pinpointed 47 genes discriminating young animals from healthy old animals and “AD-like” animals, particularly genes involved in protein synthesis pathways (Abdel Rassoul et al., 2010), while amyloid precursor protein (APP) metabolism, tau protein binding, lipid metabolism, insulin-like growth factor 1 signaling, and immune response genes are commonly reported in human patients (George et al., 2017; Wingo et al., 2019).