CREB1 and neurodegenerative disease: On the other hand, CREB1 is a co-factor of CREB and is essential for memory and synaptic plasticity in the central nervous system whereby disruption of phosphorylated CREB within the hippocampal region triggers the progression of neurodegenerative diseases like AD, Parkinson’s disease and Huntington’s disease (Lee et al., 2015).