SCIN and neoplasm: Table 2 also shows the results of multivariate analysis in the final model through the use of a multivariate Cox proportional hazard regression model, which included SCIN expression, tumor differentiation, depth of invasion infiltration, lymph node metastasis, and distant metastasis. In this model, the variables of high SCIN expression and distant metastasis were independent prognostic predictors for CRC patients. We also analyzed DFS among MLM patients using Kaplan-Meier survival analysis and found that DFS was significantly lower in patients with SCIN overexpression (P = 0.004; Figure 1D).