Based on our preliminary CRC microarray analysis, SCIN may affect the diaphanous homolog (DIAPH1), cyclin-dependent kinases (CDK2), signal transducer and activator of transcription 3 (STAT3), cyclin-dependent kinases (CDK4), EGFR, cycline dependent kinase inhibitor 2B (CDKN2B), and collagen type IV alpha 1 (COL4A1) signaling pathways. The gene discussed is COL4A1; the disease is colorectal carcinoma.