Several studies have demonstrated the involvement of autoimmune factors such as Aβ aAb, anti-angiotensin 2 type 1 receptors (anti-AT1R) aAb, intermediate neurofilament heavy (NFH) protein as primary self-antigen (pSAg), immunoglobin (Ig) positive neurons and NGF reduction in AD pathogenesis (Supplementary Table S1). Here, NGF is linked to Alzheimer disease.