Bee venom exerts an inhibitory effect in an LPS-induced mouse model of AD (Gu et al., 2015), rheumatoid arthritis (Darwish et al., 2013), PD (Kim et al., 2011), and growth of prostate cancer cells (Park et al., 2011) by regulating NF-κB activation. This evidence concerns the gene NFKB1 and rheumatoid arthritis.