We examined the influence of CNO (0.5 mg/kg) administration in C57BL/6J mice, the background strain for the bigenic CamKIIα-tTA:TetO-hM3Dq and CamKIIα-tTA:TetO-hM4Di mouse lines, on anxiety and despair-like behaviours (Figure 6A). Here, CAMK2A is linked to Anxiety.