CAMK2A and Anxiety: Both optogenetic and chemogenetic activation of CamKIIα-positive mPFC neurons using viral strategies has been shown to decrease anxiety-like behaviour (Wang et al., 2015; Pati et al., 2018), which is consistent with our result of decline in anxiety-like behaviour following broad activation of CamKIIα-positive forebrain excitatory neurons using the CamKIIα-tTA:TetO-hM3Dq bigenic mouse line.