Other than TDP-43 or SOD1, FUS plays an active role in the etiology of ALS owing to its presence in inclusions in a small percentage of ALS patients (Ling et al., 2013), and it containing several ALS-associated mutations (Kwiatkowski et al., 2009; Vance et al., 2009). This evidence concerns the gene FUS and amyotrophic lateral sclerosis.