TARDBP and amyotrophic lateral sclerosis: Cytoskeletal dynamics can also be affected by ALS-associated RBP mutants, for example, ALS-associated mutations in TDP-43 can alter the transport dynamics and viscosity of transport RNPs (Alami et al., 2014; Gopal et al., 2017), potentially resulting in impaired delivery of mRNA to the axons of motor neurons.