Furthermore, inclusions in sALS patient tissue that are observed to be non-linear at the micron scale are found to have a linear filamentous structure at the scale of tens of nanometers (Lowe et al., 1988; Lowe, 1994), suggesting potential amyloid-like aggregation is associated with TDP-43-related ALS. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.