Interestingly, TDP-43, SOD1, and FUS, which are the primary components of inclusions in ALS patient tissue (Ling et al., 2013), are shown to be supersaturated (expressed at levels higher than their predicted solubility) in spinal motor neurons (Ciryam et al., 2017). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.