Immunohistochemical studies of post-mortem tissue from both fALS and sALS patients with SOD1 misfolding-specific antibodies have revealed a potential role for the misfolding of WT SOD1 in all ALS (Bosco et al., 2010; Forsberg et al., 2010, 2011, 2019; Pokrishevsky et al., 2012; Paré et al., 2018), however, this is a contentious idea (Liu et al., 2009; Kerman et al., 2010; Da Cruz et al., 2017). Here, SOD1 is linked to amyotrophic lateral sclerosis.