FUS and amyotrophic lateral sclerosis: Previous studies investigating ALS-associated mutations in both FUS (Murakami et al., 2015; Patel et al., 2015) and hnRNPA1 (Molliex et al., 2015) have highlighted their capacity to mature/age from a liquid-like state to more solid gels composed of fibrillar structures under conditions that promote phase transition.