An increasing number of RNA metabolism-related genes have been identified to carry ALS-associated mutations, including heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) and heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1; Kim et al., 2013), matrin-3 (Johnson et al., 2014), TIA-1 cytotoxic granule-associated RNA binding protein (Mackenzie et al., 2017), and TATA-box binding protein associated factor 15 (TAF-15; Couthouis et al., 2011; Ticozzi et al., 2011). The gene discussed is TAF15; the disease is amyotrophic lateral sclerosis.