MTOR and diabetes mellitus: In accordance with earlier studies showing that the dysfunction in the PI3K/AKT/mTOR pathway is manifested in diabetes (Bathina and Das, 2018) as well as many neurological diseases (Wang et al., 2017), our experiment indicated that activation of the PI3K/Akt/mTOR pathway was reduced in alloxan-treated mice, whereas treatment with CARB enhanced the PI3K/Akt/mTOR pathway.