In fact, it has been shown that many tumor‐related genes become affected by CTCF expression changes, including p53, retinoblastoma protein, c‐myc, insulin‐like growth factor 2, p14, p16, and Fox0 (Fiorentino and Giordano, 2012; Shan et al., 2019). This evidence concerns the gene TP53 and neoplasm.