The increase in the percentage of CTCF expression for stage and lymph node metastasis was restricted to the low CTCF group and not seen in the high group, indicating that grouping in CTCF negative vs. positive as shown in Fig. 4 is the more appropriate model for the prognostic effect of CTCF in prostate cancer (Tables S2 and S3). Here, CTCF is linked to Familial prostate cancer.